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Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain
Synaptotagmin interaction with anionic lipid (phosphatidylserine/phosphatidylinositol) containing membranes, both in the absence and presence of calcium ions (Ca(2+)), is critical to its central role in orchestrating neurotransmitter release. The molecular surfaces involved, namely the conserved pol...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581758/ https://www.ncbi.nlm.nih.gov/pubmed/33093513 http://dx.doi.org/10.1038/s41598-020-74923-y |