Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches

Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have highlighted that these mutations reduce protein affinities within the RNA polymerase comple...

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Detalles Bibliográficos
Autores principales: Portelli, Stephanie, Myung, Yoochan, Furnham, Nicholas, Vedithi, Sundeep Chaitanya, Pires, Douglas E. V., Ascher, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581776/
https://www.ncbi.nlm.nih.gov/pubmed/33093532
http://dx.doi.org/10.1038/s41598-020-74648-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581776/
https://www.ncbi.nlm.nih.gov/pubmed/33093532
http://dx.doi.org/10.1038/s41598-020-74648-y

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