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The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission

Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature...

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Detalles Bibliográficos
Autores principales: Wierda, Keimpe D. B., Toft-Bertelsen, Trine L., Gøtzsche, Casper R., Pedersen, Ellis, Korshunova, Irina, Nielsen, Janne, Bang, Marie Louise, Kønig, Andreas B., Owczarek, Sylwia, Gjørlund, Michelle D., Schupp, Melanie, Bock, Elisabeth, Sørensen, Jakob B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582164/
https://www.ncbi.nlm.nih.gov/pubmed/33093500
http://dx.doi.org/10.1038/s41598-020-75047-z