Cargando…
The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission
Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature...
Autores principales: | Wierda, Keimpe D. B., Toft-Bertelsen, Trine L., Gøtzsche, Casper R., Pedersen, Ellis, Korshunova, Irina, Nielsen, Janne, Bang, Marie Louise, Kønig, Andreas B., Owczarek, Sylwia, Gjørlund, Michelle D., Schupp, Melanie, Bock, Elisabeth, Sørensen, Jakob B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582164/ https://www.ncbi.nlm.nih.gov/pubmed/33093500 http://dx.doi.org/10.1038/s41598-020-75047-z |
Ejemplares similares
-
A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory impairment
por: Korshunova, Irina, et al.
Publicado: (2015) -
Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2
por: Gjørlund, Michelle D., et al.
Publicado: (2017) -
SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function
por: Ribeiro, Luís F., et al.
Publicado: (2019) -
Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”
por: Owczarek, Sylwia, et al.
Publicado: (2015) -
Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons
por: Borcel, Erika, et al.
Publicado: (2016)