Solvent Free Three-Component Synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type Compounds from L-tryptophan: DFT-B3LYP Calculations for the Reaction Mechanism and 3H-pyrrol-3-one↔1H-pyrrol-3-ol Tautomeric Equilibrium

In this paper, we describe the solvent-free three-component synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type compounds from L-tryptophan. The first step of the synthetic methodology involved the esterification of L-tryptophan in excellent yields (93–98%). Equimolar mixtures of alkyl 2-aminoeste...

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Detalles Bibliográficos
Autores principales: Quiroga, Diego, Becerra, Lili Dahiana, Coy-Barrera, Ericsson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582317/
https://www.ncbi.nlm.nih.gov/pubmed/32992704
http://dx.doi.org/10.3390/molecules25194402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582317/
https://www.ncbi.nlm.nih.gov/pubmed/32992704
http://dx.doi.org/10.3390/molecules25194402

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