A Splice Intervention Therapy for Autosomal Recessive Juvenile Parkinson’s Disease Arising from Parkin Mutations

Parkin-type autosomal recessive juvenile-onset Parkinson’s disease is caused by mutations in the PRKN gene and accounts for 50% of all autosomal recessive Parkinsonism cases. Parkin is a neuroprotective protein that has dual functions as an E3 ligase in the ubiquitin–proteasome system and as a trans...

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Detalles Bibliográficos
Autores principales: Li, Dunhui, Aung-Htut, May T., Ham, Kristin A., Fletcher, Sue, Wilton, Steve D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582384/
https://www.ncbi.nlm.nih.gov/pubmed/33019779
http://dx.doi.org/10.3390/ijms21197282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582384/
https://www.ncbi.nlm.nih.gov/pubmed/33019779
http://dx.doi.org/10.3390/ijms21197282

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