Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes

Uptake transporter organic anion transporting polypeptides (OATPs), efflux transporters (P-gp, BCRP and MRP2) and cytochrome P450 enzymes (CYP450s) are widely expressed in the liver, intestine or kidney. They coordinately work to control drug disposition, termed as “interplay of transporters and enz...

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Detalles Bibliográficos
Autores principales: Yang, Yiting, Li, Ping, Zhang, Zexin, Wang, Zhongjian, Liu, Li, Liu, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582433/
https://www.ncbi.nlm.nih.gov/pubmed/32987693
http://dx.doi.org/10.3390/ijms21197023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582433/
https://www.ncbi.nlm.nih.gov/pubmed/32987693
http://dx.doi.org/10.3390/ijms21197023

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