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Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits

Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterized by a high content of polyphenolic compounds and...

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Autores principales: Kolniak-Ostek, Joanna, Kłopotowska, Dagmara, Rutkowski, Krzysztof P., Skorupińska, Anna, Kruczyńska, Dorota E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582546/
https://www.ncbi.nlm.nih.gov/pubmed/32992651
http://dx.doi.org/10.3390/molecules25194444
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author Kolniak-Ostek, Joanna
Kłopotowska, Dagmara
Rutkowski, Krzysztof P.
Skorupińska, Anna
Kruczyńska, Dorota E.
author_facet Kolniak-Ostek, Joanna
Kłopotowska, Dagmara
Rutkowski, Krzysztof P.
Skorupińska, Anna
Kruczyńska, Dorota E.
author_sort Kolniak-Ostek, Joanna
collection PubMed
description Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterized by a high content of polyphenolic compounds and antioxidant capacity, include pear fruits. In this study, the concentrations of bioactive compounds, as well as the antioxidant, anti-inflammatory, and antiproliferative activity in fruits of five selected pear cultivars were determined and compared. LC–MS and UPLC–PDA methods were used to determine the polyphenolic, carotenoid, chlorophyll, and triterpenoid profiles and content, and the antioxidant activity was analyzed using DPPH and ferric-reducing ability of plasma (FRAP) tests. The anti-inflammatory activity was determined against COX-1 and COX-2 enzymes. The cytotoxic activity of the test compounds was assessed against six tumor cell lines. The results showed that the major group of phenolic compounds in all cultivars was phenolic acids. In the group of chromoplastic pigments, chlorophyllide a and 9-cis-β-carotene were the major compounds, while in the triterpene group, ursolic acid was dominant. The antioxidant potential correlated with the content of polyphenols and carotenoids, and was the strongest for the ‘Radana’ cultivar. The highest antiproliferative activity in all varieties was established for bladder cancer.
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spelling pubmed-75825462020-10-29 Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits Kolniak-Ostek, Joanna Kłopotowska, Dagmara Rutkowski, Krzysztof P. Skorupińska, Anna Kruczyńska, Dorota E. Molecules Article Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterized by a high content of polyphenolic compounds and antioxidant capacity, include pear fruits. In this study, the concentrations of bioactive compounds, as well as the antioxidant, anti-inflammatory, and antiproliferative activity in fruits of five selected pear cultivars were determined and compared. LC–MS and UPLC–PDA methods were used to determine the polyphenolic, carotenoid, chlorophyll, and triterpenoid profiles and content, and the antioxidant activity was analyzed using DPPH and ferric-reducing ability of plasma (FRAP) tests. The anti-inflammatory activity was determined against COX-1 and COX-2 enzymes. The cytotoxic activity of the test compounds was assessed against six tumor cell lines. The results showed that the major group of phenolic compounds in all cultivars was phenolic acids. In the group of chromoplastic pigments, chlorophyllide a and 9-cis-β-carotene were the major compounds, while in the triterpene group, ursolic acid was dominant. The antioxidant potential correlated with the content of polyphenols and carotenoids, and was the strongest for the ‘Radana’ cultivar. The highest antiproliferative activity in all varieties was established for bladder cancer. MDPI 2020-09-27 /pmc/articles/PMC7582546/ /pubmed/32992651 http://dx.doi.org/10.3390/molecules25194444 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kolniak-Ostek, Joanna
Kłopotowska, Dagmara
Rutkowski, Krzysztof P.
Skorupińska, Anna
Kruczyńska, Dorota E.
Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title_full Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title_fullStr Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title_full_unstemmed Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title_short Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
title_sort bioactive compounds and health-promoting properties of pear (pyrus communis l.) fruits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582546/
https://www.ncbi.nlm.nih.gov/pubmed/32992651
http://dx.doi.org/10.3390/molecules25194444
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