Cytochrome P450 Can Epoxidize an Oxepin to a Reactive 2,3-Epoxyoxepin Intermediate: Potential Insights into Metabolic Ring-Opening of Benzene

Dimethyldioxirane epoxidizes 4,5-benzoxepin to form the reactive 2,3-epoxyoxepin intermediate followed by very rapid ring-opening to an o-xylylene that immediately isomerizes to the stable product 1H-2-benzopyran-1-carboxaldehyde. The present study demonstrates that separate incubations of 4,5-benzo...

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Detalles Bibliográficos
Autores principales: Weaver-Guevara, Holly M., Fitzgerald, Ryan W., Cote, Noah A., Greenberg, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582548/
https://www.ncbi.nlm.nih.gov/pubmed/33023027
http://dx.doi.org/10.3390/molecules25194542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582548/
https://www.ncbi.nlm.nih.gov/pubmed/33023027
http://dx.doi.org/10.3390/molecules25194542

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