Cargando…

4-Oxatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorders. NGP1-01, a polycyclic amine, has been shown to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Egunlusi, Ayodeji O., Malan, Sarel F., Omoruyi, Sylvester I., Ekpo, Okobi E., Joubert, Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582567/ https://www.ncbi.nlm.nih.gov/pubmed/33027964 http://dx.doi.org/10.3390/molecules25194552

Ejemplares similares

4-(2-Aminophenyl)-10-oxa-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Li, Jian
Publicado: (2011)

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
por: Mzezewa, Sheunopa C., et al.
Publicado: (2021)

exo-1,7-Dimethyl-4-phenyl-10-oxa-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Pineda-Contreras, Armando, et al.
Publicado: (2013)

exo,exo-4-(2-Hydroxyethyl)-10-oxa-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Tan, Xue-Jie, et al.
Publicado: (2012)

2,6-Dimethyl-4-oxo-3-oxatricyclo[5.2.1.0(2,6)]decane-1-carboxamide
por: Grytsai, Oleksandr, et al.
Publicado: (2013)

1,7,8,9,10,10-Hexachloro-4-(2-phenylethyl)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Manohar, R., et al.
Publicado: (2011)

1,7,8,9,10,10-Hexachloro-4-(thiophen-2-ylmethyl)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Manohar, R., et al.
Publicado: (2011)

Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Kossakowski, Jerzy, et al.
Publicado: (2009)

Crystal structure of 1,7,8,9-tetrachloro-4-(2-fluorobenzyl)-10,10-dimethoxy-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Zhong, Jia-liang, et al.
Publicado: (2015)

Crystal structure of 1,7,8,9-tetrachloro-4-(3,5-dichlorobenzyl)-10,10-dimethoxy-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
por: Liu, He, et al.
Publicado: (2015)

GRP78/BIP/HSPA5 as a Therapeutic Target in Models of Parkinson's Disease: A Mini Review
por: Enogieru, Adaze Bijou, et al.
Publicado: (2019)

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents
por: Kapp, Erika, et al.
Publicado: (2017)

4-(3,5-Dioxo-10-oxa-4-azatricyclo[5.2.1.0(2,6)]decan-4-yl)-10-oxa-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione
por: Wang, Peng-Peng, et al.
Publicado: (2012)

2-(3,5-Dioxo-4-azatricyclo[5.2.1.0(2,6)]dec-8-en-4-yl)acetic acid
por: Akkurt, Mehmet, et al.
Publicado: (2013)

Neuroprotective Activities of Boophone haemanthoides (Amaryllidaceae) Extract and Its Chemical Constituents
por: Ibrakaw, Abobaker S., et al.
Publicado: (2020)

1,10,10-Trimethyl-5-phenyl-3-oxa-4-azatricyclo[5.2.1.0(2,6)]dec-4-en-2-ol
por: Boualy, Brahim, et al.
Publicado: (2013)

(+)-(1S,5R,10S)-11,11-Dimethyl-4-oxatricyclo[8.4.0.0(1,5)]tetradecane-3,12-dione
por: Gallucci, Judith C., et al.
Publicado: (2007)

3-(2-Furylmethylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
por: Zeng, Wu-Lan, et al.
Publicado: (2009)

exo-4-[(1H-Benzimidazol-2-yl)methyl]-10-oxa-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione
por: Li, Shi-Kun, et al.
Publicado: (2011)

Neuroprotective Activities of Crossyne flava Bulbs and Amaryllidaceae Alkaloids: Implications for Parkinson’s Disease
por: Omoruyi, Sylvester I., et al.
Publicado: (2021)

3-[(5-Methylfuran-2-yl)methylene]-1,5-dioxaspiro[5.5]undecane-2,4-dione
por: Zeng, Wu-Lan, et al.
Publicado: (2009)

Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies
por: Winklehner, Michael, et al.
Publicado: (2022)

2-(10′,10′-Dimethyl-3′-sulfanylidene-4′-azatricyclo[5.2.1.0(1,5)]decan-2′-yl)-10,10-dimethyl-4-azatricyclo[5.2.1.0(1,5)]decane-3-thione
por: Walker, Ashley, et al.
Publicado: (2013)

4-Phenyl-1,2,4-triazaspiro[4.5]dec-1-ene-3-thione
por: Akkurt, Mehmet, et al.
Publicado: (2013)

1,5-Bis(pentafluorophenyl)-3-phenylpent-2-ene-1,5-dione
por: Schwarzer, Anke, et al.
Publicado: (2009)

Milestone Dec. 85/5
Publicado: (1985)

Synthesis of bridged tricyclo[5.2.1.0(1,5)]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
por: Chen, Jiachang, et al.
Publicado: (2020)

Asymmetric syntheses of 8-oxabicyclo[3,2,1]octane and 11-oxatricyclo[5.3.1.0]undecane from glycals
por: Liao, Hongze, et al.
Publicado: (2017)

5-(4-Bromoanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
por: Shi, Jian-You, et al.
Publicado: (2009)

5-(4-Chloroanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
por: Yang, Jin-Cheng, et al.
Publicado: (2009)

Synthesis and Biological Evaluations of NO-Donating Oxa- and Aza-Pentacycloundecane Derivatives as Potential Neuroprotective Candidates
por: Sharma, Rajan, et al.
Publicado: (2018)

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents
por: Zondagh, Luke S., et al.
Publicado: (2020)

6-Methylideneandrost-4-ene-3,17-dione
por: Andrade, L. C. R., et al.
Publicado: (2012)

3,8-Dimethylacenaphthylene-1,2-dione
por: He, Shu-hua
Publicado: (2011)

5-[(4-Acetylphenyl)aminomethylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
por: Li, Rui, et al.
Publicado: (2009)

2,2-Dimethyl-5-(2-naphthylaminomethylene)-1,3-dioxane-4,6-dione
por: Li, Rui, et al.
Publicado: (2009)

2,2-Dimethyl-5-[(3-nitroanilino)methylene]-1,3-dioxane-4,6-dione
por: Zhou, Meng, et al.
Publicado: (2009)

2,2-Dimethyl-5-(1-naphthylaminomethylene)-1,3-dioxane-4,6-dione
por: Li, Zhi, et al.
Publicado: (2009)

Microwave Optimized Synthesis of N-(adamantan-1-yl)-4-[(adamantan-1-yl)-sulfamoyl]benzamide and Its Derivatives for Anti-Dengue Virus Activity
por: Joubert, Jacques, et al.
Publicado: (2018)

Editorial: Channel Modulation in Neurodegeneration and Neuroprotection
por: Joubert, Jacques, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_obiokci5aladamqbc9t7vbip7a