In Situ Gelling Systems Using Pluronic F127 Enhance Corneal Permeability of Indomethacin Nanocrystals

We previously designed an ophthalmic dispersion containing indomethacin nanocrystals (IMC-NCs), showing that multiple energy-dependent endocytoses led to the enhanced absorption of drugs from ocular dosage forms. In this study, we attempted to prepare Pluronic F-127 (PLF-127)-based in situ gel (ISG)...

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Detalles Bibliográficos
Autores principales: Nagai, Noriaki, Isaka, Takumi, Deguchi, Saori, Minami, Misa, Yamaguchi, Mizuki, Otake, Hiroko, Okamoto, Norio, Nakazawa, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582645/
https://www.ncbi.nlm.nih.gov/pubmed/32992931
http://dx.doi.org/10.3390/ijms21197083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582645/
https://www.ncbi.nlm.nih.gov/pubmed/32992931
http://dx.doi.org/10.3390/ijms21197083

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