Cargando…

In Situ Gelling Systems Using Pluronic F127 Enhance Corneal Permeability of Indomethacin Nanocrystals

We previously designed an ophthalmic dispersion containing indomethacin nanocrystals (IMC-NCs), showing that multiple energy-dependent endocytoses led to the enhanced absorption of drugs from ocular dosage forms. In this study, we attempted to prepare Pluronic F-127 (PLF-127)-based in situ gel (ISG)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagai, Noriaki, Isaka, Takumi, Deguchi, Saori, Minami, Misa, Yamaguchi, Mizuki, Otake, Hiroko, Okamoto, Norio, Nakazawa, Yosuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582645/ https://www.ncbi.nlm.nih.gov/pubmed/32992931 http://dx.doi.org/10.3390/ijms21197083

Ejemplares similares

Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding
por: Nagai, Noriaki, et al.
Publicado: (2019)

An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva
por: Nagai, Noriaki, et al.
Publicado: (2020)

Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
por: Deguchi, Saori, et al.
Publicado: (2023)

Energy-Dependent Endocytosis Is Involved in the Absorption of Indomethacin Nanoparticles in the Small Intestine
por: Ishii, Miyu, et al.
Publicado: (2019)

Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles Based on Protamine Zinc Insulin in the Rabbit
por: Deguchi, Saori, et al.
Publicado: (2021)

Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig
por: Otake, Hiroko, et al.
Publicado: (2021)

Combination with l-Menthol Enhances Transdermal Penetration of Indomethacin Solid Nanoparticles
por: Nagai, Noriaki, et al.
Publicado: (2019)

In Situ Gel Incorporating Disulfiram Nanoparticles Rescues the Retinal Dysfunction via ATP Collapse in Otsuka Long–Evans Tokushima Fatty Rats
por: Deguchi, Saori, et al.
Publicado: (2020)

Nasal Absorption Enhancement of Mometasone Furoate Nanocrystal Dispersions
por: Masuda, Shuya, et al.
Publicado: (2023)

Energy-dependent endocytosis is responsible for drug transcorneal penetration following the instillation of ophthalmic formulations containing indomethacin nanoparticles
por: Nagai, Noriaki, et al.
Publicado: (2019)

Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic Effect of Rebamipide in a Hamster Model for Oral Mucositis
por: Nagai, Noriaki, et al.
Publicado: (2020)

Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles
por: Minami, Misa, et al.
Publicado: (2021)

Ophthalmic Formulation Containing Nilvadipine Nanoparticles Prevents Retinal Dysfunction in Rats Injected with Streptozotocin
por: Deguchi, Saori, et al.
Publicado: (2017)

Effect of inner physical properties on powder adhesion in inhalation capsules in case of a high resistance device
por: Otake, Hiroko, et al.
Publicado: (2021)

MPC Polymer Promotes Recovery from Dry Eye via Stabilization of the Ocular Surface
por: Nagai, Noriaki, et al.
Publicado: (2021)

Therapeutic Potential of a Combination of Magnesium Hydroxide Nanoparticles and Sericin for Epithelial Corneal Wound Healing
por: Nagai, Noriaki, et al.
Publicado: (2019)

Development of Sustained-Release Ophthalmic Formulation Based on Tranilast Solid Nanoparticles
por: Minami, Misa, et al.
Publicado: (2020)

Transdermal System Based on Solid Cilostazol Nanoparticles Attenuates Ischemia/Reperfusion-Induced Brain Injury in Mice
por: Otake, Hiroko, et al.
Publicado: (2021)

Therapeutic Effect of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced Diabetic Rats
por: Nagai, Noriaki, et al.
Publicado: (2017)

Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats
por: Nagai, Noriaki, et al.
Publicado: (2020)

Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats
por: Goto, Ryoka, et al.
Publicado: (2021)

Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats
por: Deguchi, Saori, et al.
Publicado: (2022)

Orally disintegrating tablets containing famotidine nanoparticles provide high intestinal absorbability via the energy-dependent endocytosis pathway
por: Nagai, Noriaki, et al.
Publicado: (2023)

Morphology and performance of polyvinyl chloride membrane modified with Pluronic F127
por: Arahman, Nasrul, et al.
Publicado: (2018)

Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
por: Lupu, Alexandra, et al.
Publicado: (2023)

Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair
por: Li, Shanshan, et al.
Publicado: (2023)

Enhancement in Corneal Permeability of Dissolved Carteolol by Its Combination with Magnesium Hydroxide Nanoparticles
por: Nagai, Noriaki, et al.
Publicado: (2018)

Oral Administration System Based on Meloxicam Nanocrystals: Decreased Dose Due to High Bioavailability Attenuates Risk of Gastrointestinal Side Effects
por: Nagai, Noriaki, et al.
Publicado: (2020)

Chitosan/Pluronic F127 Thermosensitive Hydrogel as an Injectable Dexamethasone Delivery Carrier
por: García-Couce, Jomarien, et al.
Publicado: (2022)

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems
por: Lupu, Alexandra, et al.
Publicado: (2023)

Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine
por: Deguchi, Saori, et al.
Publicado: (2021)

Design of a Transdermal Sustained Release Formulation Based on Water-Soluble Ointment Incorporating Tulobuterol Nanoparticles
por: Nagai, Noriaki, et al.
Publicado: (2022)

Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation
por: Liu, Yuling, et al.
Publicado: (2017)

Visualization of supramolecular structure of Pluronic F127 micellar hydrogels using cryo-TEM
por: da Silva, Laura C.E., et al.
Publicado: (2020)

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir
por: Di Donato, Cristina, et al.
Publicado: (2020)

NBT-Pluronic F-127 Hydrogels Printed on Flat Textiles as UV Radiation Sensors
por: Sąsiadek, Elżbieta, et al.
Publicado: (2021)

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization
por: Zou, Shuaijun, et al.
Publicado: (2021)

Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy
por: Khaliq, Nisar Ul, et al.
Publicado: (2023)

Solutol(®)HS15+pluronicF127 and Solutol(®)HS15+pluronicL61 mixed micelle systems for oral delivery of genistein
por: Ding, Pinggang, et al.
Publicado: (2019)

Fixed-Combination Eye Drops Based on Fluorometholone Nanoparticles and Bromfenac/Levofloxacin Solution Improve Drug Corneal Penetration
por: Otake, Hiroko, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pmq0rbt1vd7vll355peiufd9cl