Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors

Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids, largely responsible for extracellular lysophosphatidic acid (LPA) production. LPA is a bioactive growth-factor-like lysophospholipid that exerts pleiotropic effects in almost all cell types, exerted through at least six...

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Detalles Bibliográficos
Autores principales: Magkrioti, Christiana, Kaffe, Eleanna, Stylianaki, Elli-Anna, Sidahmet, Camelia, Melagraki, Georgia, Afantitis, Antreas, Matralis, Alexios N., Aidinis, Vassilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582705/
https://www.ncbi.nlm.nih.gov/pubmed/32977539
http://dx.doi.org/10.3390/ijms21197002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582705/
https://www.ncbi.nlm.nih.gov/pubmed/32977539
http://dx.doi.org/10.3390/ijms21197002

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