Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M(pro))

A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds. Also, dehydrative-cyclocondensation of 2 with active methylene compounds or anhydrides gave the respective pyarzole or pyrazine derivatives...

Descripción completa

Detalles Bibliográficos
Autores principales: Abu-Melha, Sraa, Edrees, Mastoura M., Riyadh, Sayed M., Abdelaziz, Mohamad R., Elfiky, Abdo A., Gomha, Sobhi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582706/
https://www.ncbi.nlm.nih.gov/pubmed/33036293
http://dx.doi.org/10.3390/molecules25194565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582706/
https://www.ncbi.nlm.nih.gov/pubmed/33036293
http://dx.doi.org/10.3390/molecules25194565

Ejemplares similares