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Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M(pro))

A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds. Also, dehydrative-cyclocondensation of 2 with active methylene compounds or anhydrides gave the respective pyarzole or pyrazine derivatives...

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Detalles Bibliográficos
Autores principales:	Abu-Melha, Sraa, Edrees, Mastoura M., Riyadh, Sayed M., Abdelaziz, Mohamad R., Elfiky, Abdo A., Gomha, Sobhi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582706/ https://www.ncbi.nlm.nih.gov/pubmed/33036293 http://dx.doi.org/10.3390/molecules25194565

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