Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

I(Kr) current, a major component of cardiac repolarization, is mediated by human Ether-à-go-go-Related Gene (hERG, K(v)11.1) potassium channels. The blockage of these channels by pharmacological compounds is associated to drug-induced long QT syndrome (LQTS), which is a life-threatening disorder cha...

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Detalles Bibliográficos
Autores principales: De Waard, Stephan, Montnach, Jérôme, Ribeiro, Barbara, Nicolas, Sébastien, Forest, Virginie, Charpentier, Flavien, Mangoni, Matteo Elia, Gaborit, Nathalie, Ronjat, Michel, Loussouarn, Gildas, Lemarchand, Patricia, De Waard, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582727/
https://www.ncbi.nlm.nih.gov/pubmed/32998413
http://dx.doi.org/10.3390/ijms21197167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582727/
https://www.ncbi.nlm.nih.gov/pubmed/32998413
http://dx.doi.org/10.3390/ijms21197167

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