Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors

Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used at subinhibitory concentrations. Nitrogen-containing glycomimetics such as aza- or iminosugars are known to behave as PCs for lysosomal storage disorders (LSDs). As part of our res...

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Detalles Bibliográficos
Autores principales: Davighi, Maria Giulia, Clemente, Francesca, Matassini, Camilla, Morrone, Amelia, Goti, Andrea, Martínez-Bailén, Macarena, Cardona, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582770/
https://www.ncbi.nlm.nih.gov/pubmed/33023214
http://dx.doi.org/10.3390/molecules25194526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582770/
https://www.ncbi.nlm.nih.gov/pubmed/33023214
http://dx.doi.org/10.3390/molecules25194526

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