Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model

Activation of the nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome plays an important role in ocular neovascularization. In our study, we found that the expression and activation levels of NLRP3 inflammasome components, including NLRP3, an apo...

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Detalles Bibliográficos
Autores principales: Sui, Ailing, Chen, Xiuping, Shen, Jikui, Demetriades, Anna M., Yao, Yiyun, Yao, Yixuan, Zhu, Yanji, Shen, Xi, Xie, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582915/
https://www.ncbi.nlm.nih.gov/pubmed/33093455
http://dx.doi.org/10.1038/s41419-020-03076-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582915/
https://www.ncbi.nlm.nih.gov/pubmed/33093455
http://dx.doi.org/10.1038/s41419-020-03076-7

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