3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis

Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral reverse transcriptase with epsilon (ε), a cis-acting regulatory signal located at the 5’ terminus of pre-genomic RNA (pgRNA), and several host-encoded chaperone proteins. Binding of the...

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Detalles Bibliográficos
Autores principales: Bak, Ellen, Miller, Jennifer T., Noronha, Andrea, Tavis, John, Gallicchio, Emilio, Murelli, Ryan P., Le Grice, Stuart F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583054/
https://www.ncbi.nlm.nih.gov/pubmed/32992516
http://dx.doi.org/10.3390/molecules25194434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583054/
https://www.ncbi.nlm.nih.gov/pubmed/32992516
http://dx.doi.org/10.3390/molecules25194434

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