Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

Dengue virus (DENV) infects an estimated 390 million people each year worldwide. As tetravalent DENV vaccines have variable efficacy against DENV serotype 2 (DENV2), we evaluated the role of genetic diversity within the pre-membrane (prM) and envelope (E) proteins of DENV2 on vaccine performance. We...

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Detalles Bibliográficos
Autores principales: Martinez, David R., Yount, Boyd, Nivarthi, Usha, Munt, Jennifer E., Delacruz, Matthew J., Whitehead, Stephen S., Durbin, Anna P., de Silva, Aravinda M., Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583086/
https://www.ncbi.nlm.nih.gov/pubmed/33027653
http://dx.doi.org/10.1016/j.celrep.2020.108226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583086/
https://www.ncbi.nlm.nih.gov/pubmed/33027653
http://dx.doi.org/10.1016/j.celrep.2020.108226

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