Nanoscale flow cytometry reveals interpatient variability in HIV protease activity that correlates with viral infectivity and identifies drug-resistant viruses

HIV encodes an aspartyl protease that is activated during, or shortly after, budding of viral particles from the surface of infected cells. Protease-mediated cleavage of viral polyproteins is essential to generating infectious viruses, a process known as ‘maturation’ that is the target of FDA-approv...

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Detalles Bibliográficos
Autores principales: Bonar, Michał M., Tabler, Caroline O., Haqqani, Aiman A., Lapointe, Lauren E., Galiatsos, Jake A., Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Tilton, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583244/
https://www.ncbi.nlm.nih.gov/pubmed/33093566
http://dx.doi.org/10.1038/s41598-020-75118-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583244/
https://www.ncbi.nlm.nih.gov/pubmed/33093566
http://dx.doi.org/10.1038/s41598-020-75118-1

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