Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Isomerization reactions are fundamental in biology. Lactate racemase, which isomerizes L- and D-lactate, is composed of the LarA protein and a nickel-containing cofactor, the nickel-pincer nucleotide (NPN). In this study, we show that LarA is part of a superfamily containing many different enzymes....

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Detalles Bibliográficos
Autores principales: Desguin, Benoît, Urdiain-Arraiza, Julian, Da Costa, Matthieu, Fellner, Matthias, Hu, Jian, Hausinger, Robert P., Desmet, Tom, Hols, Pascal, Soumillion, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583248/
https://www.ncbi.nlm.nih.gov/pubmed/33093595
http://dx.doi.org/10.1038/s41598-020-74802-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583248/
https://www.ncbi.nlm.nih.gov/pubmed/33093595
http://dx.doi.org/10.1038/s41598-020-74802-6

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