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Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases
Isomerization reactions are fundamental in biology. Lactate racemase, which isomerizes L- and D-lactate, is composed of the LarA protein and a nickel-containing cofactor, the nickel-pincer nucleotide (NPN). In this study, we show that LarA is part of a superfamily containing many different enzymes....
Autores principales: | Desguin, Benoît, Urdiain-Arraiza, Julian, Da Costa, Matthieu, Fellner, Matthias, Hu, Jian, Hausinger, Robert P., Desmet, Tom, Hols, Pascal, Soumillion, Patrice |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583248/ https://www.ncbi.nlm.nih.gov/pubmed/33093595 http://dx.doi.org/10.1038/s41598-020-74802-6 |
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