Senolytic CAR T cells reverse senescence-associated pathologies
Cellular senescence is characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment(1,2). Physiologically, senescence serves as a tumor suppressive mechanism that prevents the expansion of premalignant cells(3,4) and plays a beneficial role in wound he...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583560/ https://www.ncbi.nlm.nih.gov/pubmed/32555459 http://dx.doi.org/10.1038/s41586-020-2403-9 |