Senolytic CAR T cells reverse senescence-associated pathologies

Cellular senescence is characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment(1,2). Physiologically, senescence serves as a tumor suppressive mechanism that prevents the expansion of premalignant cells(3,4) and plays a beneficial role in wound he...

Descripción completa

Detalles Bibliográficos
Autores principales: Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583560/
https://www.ncbi.nlm.nih.gov/pubmed/32555459
http://dx.doi.org/10.1038/s41586-020-2403-9

Ejemplares similares

Ejemplares similares