Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants

Reduced culture temperature is an increasingly popular practice to improve recombinant protein yields in CHO cells. Recent studies have attributed the enhancement of protein titers at sub-physiological temperatures to increased mRNA levels as well as extended stationary phase. We observed that reduc...

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Detalles Bibliográficos
Autores principales: Mason, Megan, Sweeney, Bernadette, Cain, Katharine, Stephens, Paul, Sharfstein, Susan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583600/
https://www.ncbi.nlm.nih.gov/pubmed/33101721
http://dx.doi.org/10.3390/antib3030253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583600/
https://www.ncbi.nlm.nih.gov/pubmed/33101721
http://dx.doi.org/10.3390/antib3030253

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