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Design and Synthesis of a Chiral Halogen-Bond Donor with a Sp(3)-Hybridized Carbon–Iodine Moiety in a Chiral Fluorobissulfonyl Scaffold
The first example of a chiral halogen-bond donor with a sp(3)-hybridized carbon–iodine moiety in a fluorobissulfonyl scaffold is described. The binaphthyl backbone was designed as a chiral source and the chiral halogen-bond donor (R)-1 was synthesized from (R)-1,1′-binaphthol in 11 steps. An NMR tit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583727/ https://www.ncbi.nlm.nih.gov/pubmed/33022984 http://dx.doi.org/10.3390/molecules25194539 |