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A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43
Clozapine (CLZ) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. Recently, the World Health Organization’s (WHO) global database (VigiBase) reported the relative lethality of severe adverse reac...
Autores principales: | Okada, Motohiro, Fukuyama, Kouji, Shiroyama, Takashi, Murata, Masahiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583770/ https://www.ncbi.nlm.nih.gov/pubmed/32987640 http://dx.doi.org/10.3390/ijms21197019 |
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