The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity

A mismatch between β-oxidation and the tricarboxylic acid cycle (TCA) cycle flux in mitochondria produces an accumulation of lipid metabolic intermediates, resulting in both blunted metabolic flexibility and decreased glucose utilization in the affected cells. The ability of the cell to switch to gl...

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Detalles Bibliográficos
Autores principales: Di Cristo, Francesca, Calarco, Anna, Digilio, Filomena Anna, Sinicropi, Maria Stefania, Rosano, Camillo, Galderisi, Umberto, Melone, Mariarosa Anna Beatrice, Saturnino, Carmela, Peluso, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583931/
https://www.ncbi.nlm.nih.gov/pubmed/33050117
http://dx.doi.org/10.3390/ijms21197431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583931/
https://www.ncbi.nlm.nih.gov/pubmed/33050117
http://dx.doi.org/10.3390/ijms21197431

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