Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing

MeCP2 is an abundant protein in mature nerve cells, where it binds to DNA sequences containing methylated cytosine. Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome (RTT), provoking intensive study of the underlying molecular mechanisms. Multiple functions have been p...

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Detalles Bibliográficos
Autores principales: Chhatbar, Kashyap, Cholewa-Waclaw, Justyna, Shah, Ruth, Bird, Adrian, Sanguinetti, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584252/
https://www.ncbi.nlm.nih.gov/pubmed/33048927
http://dx.doi.org/10.1371/journal.pgen.1009087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584252/
https://www.ncbi.nlm.nih.gov/pubmed/33048927
http://dx.doi.org/10.1371/journal.pgen.1009087

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