Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

PURPOSE: To enhance the solubility and dissolution profile of simvastatin (SIM) through co-crystallization with varying ratios of nicotinamide (NIC) using various co-methods. MATERIALS AND METHODS: Twelve SIM:NIC co-crystal formulations (F01–F12) were prepared using dry grinding, slurry, liquid-assi...

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Detalles Bibliográficos
Autores principales: Khan, Fahad Mehmood, Ahmad, Mahmood, Idrees, Hafiz Arfat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584516/
https://www.ncbi.nlm.nih.gov/pubmed/33116417
http://dx.doi.org/10.2147/DDDT.S270742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584516/
https://www.ncbi.nlm.nih.gov/pubmed/33116417
http://dx.doi.org/10.2147/DDDT.S270742

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