Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease, modulating the location and severity of inflammation and fibrosis. TL1A expression is increased in inflamed mucosa and associated with fibrostenosing Crohn’s disease. Tl1a-overexpression in mice cause...

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Detalles Bibliográficos
Autores principales: Jacob, Noam, Kumagai, Kotaro, Abraham, Jay P., Shimodaira, Yosuke, Ye, Yuefang, Luu, Justin, Blackwood, Anna Y., Castanon, Sofi L., Stamps, Dalton T., Thomas, Lisa S., Gonsky, Rivkah, Shih, David Q., Michelsen, Kathrin S., Targan, Stephan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584589/
https://www.ncbi.nlm.nih.gov/pubmed/33097818
http://dx.doi.org/10.1038/s41598-020-75168-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584589/
https://www.ncbi.nlm.nih.gov/pubmed/33097818
http://dx.doi.org/10.1038/s41598-020-75168-5

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