Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures

High order oligomers are crucial for normal cell physiology, and protein function perturbed by missense mutations underlies several autosomal dominant diseases. Dynamin-2 is one of such protein forming helical oligomers that catalyze membrane fission. Mutations in this protein, where R465W is the mo...

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Detalles Bibliográficos
Autores principales: Hinostroza, Fernando, Neely, Alan, Araya-Duran, Ingrid, Marabolí, Vanessa, Canan, Jonathan, Rojas, Maximiliano, Aguayo, Daniel, Latorre, Ramón, González-Nilo, Fernando D., Cárdenas, Ana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584598/
https://www.ncbi.nlm.nih.gov/pubmed/33097808
http://dx.doi.org/10.1038/s41598-020-75216-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584598/
https://www.ncbi.nlm.nih.gov/pubmed/33097808
http://dx.doi.org/10.1038/s41598-020-75216-0

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