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Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures
High order oligomers are crucial for normal cell physiology, and protein function perturbed by missense mutations underlies several autosomal dominant diseases. Dynamin-2 is one of such protein forming helical oligomers that catalyze membrane fission. Mutations in this protein, where R465W is the mo...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584598/ https://www.ncbi.nlm.nih.gov/pubmed/33097808 http://dx.doi.org/10.1038/s41598-020-75216-0 |