Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path

Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fidelity. In proofreading, mis-incorporated nucleotides are excised through the 3′-5′ exonuclease activity of the DNA polymerase holoenzyme. The exonuclease site is distal from the polymerization site, im...

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Detalles Bibliográficos
Autores principales: Dodd, Thomas, Botto, Margherita, Paul, Fabian, Fernandez-Leiro, Rafael, Lamers, Meindert H., Ivanov, Ivaylo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584608/
https://www.ncbi.nlm.nih.gov/pubmed/33097731
http://dx.doi.org/10.1038/s41467-020-19165-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584608/
https://www.ncbi.nlm.nih.gov/pubmed/33097731
http://dx.doi.org/10.1038/s41467-020-19165-2

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