A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy

The development of genome editing systems based on the Cas9 endonuclease has greatly facilitated gene knockouts and targeted genetic alterations. Precise editing of target genes without off-target effects is crucial to prevent adverse effects in clinical applications. Although several methods have b...

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Detalles Bibliográficos
Autores principales: Matsumoto, Daisuke, Tamamura, Hirokazu, Nomura, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584632/
https://www.ncbi.nlm.nih.gov/pubmed/33097793
http://dx.doi.org/10.1038/s42003-020-01340-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584632/
https://www.ncbi.nlm.nih.gov/pubmed/33097793
http://dx.doi.org/10.1038/s42003-020-01340-2

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