Prime editing for functional repair in patient-derived disease models

Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase and reverse transcriptase, that holds promise to correct the vast majority of genetic defects. Here, we develop prime editing for primary adult stem cells grown in organoid culture models. First, we generate pr...

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Detalles Bibliográficos
Autores principales: Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584657/
https://www.ncbi.nlm.nih.gov/pubmed/33097693
http://dx.doi.org/10.1038/s41467-020-19136-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584657/
https://www.ncbi.nlm.nih.gov/pubmed/33097693
http://dx.doi.org/10.1038/s41467-020-19136-7

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