Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

To better understand host-virus genetic dependencies and find potential therapeutic targets for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar epithelial cells. Top-ranked genes cluster into dist...

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Detalles Bibliográficos
Autores principales: Daniloski, Zharko, Jordan, Tristan X., Wessels, Hans-Hermann, Hoagland, Daisy A., Kasela, Silva, Legut, Mateusz, Maniatis, Silas, Mimitou, Eleni P., Lu, Lu, Geller, Evan, Danziger, Oded, Rosenberg, Brad R., Phatnani, Hemali, Smibert, Peter, Lappalainen, Tuuli, tenOever, Benjamin R., Sanjana, Neville E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584921/
https://www.ncbi.nlm.nih.gov/pubmed/33147445
http://dx.doi.org/10.1016/j.cell.2020.10.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584921/
https://www.ncbi.nlm.nih.gov/pubmed/33147445
http://dx.doi.org/10.1016/j.cell.2020.10.030

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