Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However, tumor cells can create an immunosuppressive microenvironment to escape immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumo...

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Detalles Bibliográficos
Autores principales: Teng, Rui, Wang, Yanmeng, Lv, Nan, Zhang, Dan, Williamson, Ramone A., Lei, Lei, Chen, Ping, Lei, Li, Wang, Baiyan, Fu, Jiaqi, Liu, Xuna, He, Aili, O'Dwyer, Michael, Hu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584946/
https://www.ncbi.nlm.nih.gov/pubmed/33123602
http://dx.doi.org/10.1155/2020/4598476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584946/
https://www.ncbi.nlm.nih.gov/pubmed/33123602
http://dx.doi.org/10.1155/2020/4598476

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