An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres

In the base excision repair pathway, MYH/MUTYH DNA glycosylase prevents mutations by removing adenine mispaired with 8-oxoG, a frequent oxidative lesion. MYH glycosylase activity is enhanced by Rad9-Rad1-Hus1 (9-1-1) checkpoint clamp and SIRT6 histone/protein deacetylase. Here, we show that MYH, SIR...

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Detalles Bibliográficos
Autores principales: Tan, Jun, Wang, Xiangyu, Hwang, Bor-Jang, Gonzales, Rex, Konen, Olivia, Lan, Li, Lu, A-Lien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585086/
https://www.ncbi.nlm.nih.gov/pubmed/32991318
http://dx.doi.org/10.18632/aging.103934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585086/
https://www.ncbi.nlm.nih.gov/pubmed/32991318
http://dx.doi.org/10.18632/aging.103934

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