Cargando…

Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer

Recent reports have indicated the role of highly expressed methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) enzyme in cancers, showing poor survival; however, detailed mechanistic insight of metabolic functions of MTHFD2 have not been well-defined. Therefore, we aimed to examine the metabolic func...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Chun-Hao, Wu, Chia-Yu, Dubey, Navneet Kumar, Wei, Hong-Jian, Lu, Jui-Hua, Mao, Samantha, Liang, Joy, Liang, Yu-Hsuan, Cheng, Hsin-Chung, Deng, Win-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585109/ https://www.ncbi.nlm.nih.gov/pubmed/32759461 http://dx.doi.org/10.18632/aging.103471

Ejemplares similares

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
por: Shin, Minhye, et al.
Publicado: (2017)

Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis
por: Zhang, Hongtuan, et al.
Publicado: (2013)

Cellular Redox Homeostasis
por: Le Gal, Kristell, et al.
Publicado: (2021)

Glucose-6-Phosphate Dehydrogenase, Redox Homeostasis and Embryogenesis
por: Chen, Po-Hsiang, et al.
Publicado: (2022)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
por: Asai, Ayumu, et al.
Publicado: (2018)

Crystal structure of Thermus thermophilus methylenetetrahydrofolate dehydrogenase and determinants of thermostability
por: Maiello, Fernando, et al.
Publicado: (2020)

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
por: Zhao, Li Na, et al.
Publicado: (2022)

Hydrogen Sulfide and Cellular Redox Homeostasis
por: Xie, Zhi-Zhong, et al.
Publicado: (2016)

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)
por: Lee, Lung-Chun, et al.
Publicado: (2021)

NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis
por: Zhao, Liang, et al.
Publicado: (2021)

Modulation of cellular redox homeostasis by the endocannabinoid system
por: Lipina, Christopher, et al.
Publicado: (2016)

Micro RNAs in Regulation of Cellular Redox Homeostasis
por: Ciesielska, Sylwia, et al.
Publicado: (2021)

Editorial: Coenzyme Q Redox State and Cellular Homeostasis
por: Sanz, Alberto, et al.
Publicado: (2018)

Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer
por: Lin, Victor C., et al.
Publicado: (2016)

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer
por: Eich, Marie-Lisa, et al.
Publicado: (2019)

Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori
por: Haque, Mohammad R., et al.
Publicado: (2019)

Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation
por: Ding, Ke, et al.
Publicado: (2018)

Understanding Cellular Redox Homeostasis: A Challenge for Precision Medicine
por: Tretter, Verena, et al.
Publicado: (2021)

Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling
por: Chai, Yuh-Cherng, et al.
Publicado: (2023)

Highly Expressed FOXF1 Inhibit Non-Small-Cell Lung Cancer Growth via Inducing Tumor Suppressor and G1-Phase Cell-Cycle Arrest
por: Wu, Chia-Yu, et al.
Publicado: (2020)

In vitro characterization of an enzymatic redox cascade composed of an alcohol dehydrogenase, an enoate reductases and a Baeyer–Villiger monooxygenase
por: Oberleitner, Nikolin, et al.
Publicado: (2014)

Redox regulated peroxisome homeostasis
por: Wang, Xiaofeng, et al.
Publicado: (2014)

Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma
por: Shi, Lu-feng, et al.
Publicado: (2021)

Editorial to the Special Issue “Homeostasis: Metals and Cellular Redox and Immunity Status”
por: Michalke, Bernhard, et al.
Publicado: (2023)

Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer’s Disease
por: Wu, Yi-Hsuan, et al.
Publicado: (2023)

Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study
por: Neagos, D, et al.
Publicado: (2010)

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
por: Marengo, Barbara, et al.
Publicado: (2016)

Relevance of Cellular Redox Homeostasis for Vital Functions of Human Dental Pulp Cells
por: Gallorini, Marialucia, et al.
Publicado: (2021)

Exerkines and redox homeostasis
por: Félix-Soriano, Elisa, et al.
Publicado: (2023)

Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
por: Chen, Chun-Hsin, et al.
Publicado: (2021)

Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
por: Feng, Zichen, et al.
Publicado: (2022)

Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma
por: Zhang, Wei, et al.
Publicado: (2022)

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers
por: Staniland, Samantha, et al.
Publicado: (2014)

Characterisation of the redox centers of ethylbenzene dehydrogenase
por: Hagel, Corina, et al.
Publicado: (2021)

Multistability maintains redox homeostasis in human cells
por: Huang, Jo‐Hsi, et al.
Publicado: (2021)

Assessment of Pseudomonas aeruginosa N (5),N (10)-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target
por: Eadsforth, Thomas C., et al.
Publicado: (2012)

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance
por: He, Huan, et al.
Publicado: (2020)

Methylenetetrahydrofolate reductase and psychiatric diseases
por: Wan, Lin, et al.
Publicado: (2018)

Regulation of Cell Transformation by Rb-Controlled Redox Homeostasis
por: Zhu, Zhongling, et al.
Publicado: (2014)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
por: Ishida, Tomoaki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sk7trrbprdohfjd4meg5ukpm0e