MicroRNA-216a-3p promotes sorafenib sensitivity in hepatocellular carcinoma by downregulating MAPK14 expression

We investigated MAPK14-dependent resistance to sorafenib in hepatocellular carcinoma (HCC). Bioinformatics analysis and dual luciferase reporter assays in HCC cell lines showed that miR-216a-3p directly binds to the 3’UTR of MAPK14 mRNA and downregulates MAPK14 protein expression. Consequently, miR-...

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Detalles Bibliográficos
Autores principales: Wan, Zhong, Liu, Tingyu, Wang, Liang, Wang, Rong, Zhang, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585128/
https://www.ncbi.nlm.nih.gov/pubmed/33021963
http://dx.doi.org/10.18632/aging.103670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585128/
https://www.ncbi.nlm.nih.gov/pubmed/33021963
http://dx.doi.org/10.18632/aging.103670

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