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MicroRNA-216a-3p promotes sorafenib sensitivity in hepatocellular carcinoma by downregulating MAPK14 expression

We investigated MAPK14-dependent resistance to sorafenib in hepatocellular carcinoma (HCC). Bioinformatics analysis and dual luciferase reporter assays in HCC cell lines showed that miR-216a-3p directly binds to the 3’UTR of MAPK14 mRNA and downregulates MAPK14 protein expression. Consequently, miR-...

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Detalles Bibliográficos
Autores principales:	Wan, Zhong, Liu, Tingyu, Wang, Liang, Wang, Rong, Zhang, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585128/ https://www.ncbi.nlm.nih.gov/pubmed/33021963 http://dx.doi.org/10.18632/aging.103670

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