Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability

BACKGROUND: The accumulation of mtDNA mutations in different tissues from various mouse models has been widely studied especially in the context of mtDNA mutation-driven ageing but has been confounded by the inherent limitations of the most widely used approaches. By implementing a method to sequenc...

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Detalles Bibliográficos
Autores principales: Bagge, Emilie Kristine, Fujimori-Tonou, Noriko, Kubota-Sakashita, Mie, Kasahara, Takaoki, Kato, Tadafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585204/
https://www.ncbi.nlm.nih.gov/pubmed/33097039
http://dx.doi.org/10.1186/s12915-020-00890-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585204/
https://www.ncbi.nlm.nih.gov/pubmed/33097039
http://dx.doi.org/10.1186/s12915-020-00890-5

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