Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination

BACKGROUND: Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR). Since HDR competes with the prevailing non-homologous end joining (NHEJ) pathw...

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Detalles Bibliográficos
Autores principales: Bashir, Sanum, Dang, Tu, Rossius, Jana, Wolf, Johanna, Kühn, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585302/
https://www.ncbi.nlm.nih.gov/pubmed/33097066
http://dx.doi.org/10.1186/s12896-020-00650-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585302/
https://www.ncbi.nlm.nih.gov/pubmed/33097066
http://dx.doi.org/10.1186/s12896-020-00650-x

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