Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43

Cytoplasmic inclusion of TAR DNA-binding protein 43 (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and a subtype of frontotemporal lobar degeneration (FTLD). Recent studies have suggested that the formation of cytoplasmic TDP-43 aggregates is dependent on a liquid–liquid...

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Detalles Bibliográficos
Autores principales: Watanabe, Seiji, Inami, Hidekazu, Oiwa, Kotaro, Murata, Yuri, Sakai, Shohei, Komine, Okiru, Sobue, Akira, Iguchi, Yohei, Katsuno, Masahisa, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585435/
https://www.ncbi.nlm.nih.gov/pubmed/33097688
http://dx.doi.org/10.1038/s41419-020-03116-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585435/
https://www.ncbi.nlm.nih.gov/pubmed/33097688
http://dx.doi.org/10.1038/s41419-020-03116-2

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