Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

The family of vascular endothelial growth factor (VEGF) ligands and their interactions with VEGF receptors (VEGFRs) play important roles in both pathological and physiological angiogenesis. Hence, agonistic and antagonistic ligands targeting this signaling pathway have potential for both studies on...

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Detalles Bibliográficos
Autores principales: Güler, Rezan, Svedmark, Siri Flemming, Abouzayed, Ayman, Orlova, Anna, Löfblom, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585445/
https://www.ncbi.nlm.nih.gov/pubmed/33097752
http://dx.doi.org/10.1038/s41598-020-74560-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585445/
https://www.ncbi.nlm.nih.gov/pubmed/33097752
http://dx.doi.org/10.1038/s41598-020-74560-5

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