Dual regulatory effects of PI(4,5)P(2) on TREK-2 K(+) channel through antagonizing interaction between the alkaline residues (K(330) and R(355-357)) in the cytosolic C-terminal helix

TWIK-related two-pore domain K(+) channel-2 (TREK-2) has voltage-independent activity and shows additional activation by acidic intracellular pH (pH(i)) via neutralizing the E(332) in the cytoplasmic C terminal (Ct). We reported opposite regulations of TREK-2 by phosphatidylinositol 4,5-bisphosphate...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Sung Eun, Kim, Myoung-Hwan, Woo, Joohan, Kim, Sung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585596/
https://www.ncbi.nlm.nih.gov/pubmed/33093276
http://dx.doi.org/10.4196/kjpp.2020.24.6.555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585596/
https://www.ncbi.nlm.nih.gov/pubmed/33093276
http://dx.doi.org/10.4196/kjpp.2020.24.6.555

Ejemplares similares