Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin 1 and expression levels of sirtuin 1/2 and stimulated acetylation of forkhead...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Min Jeong, Kang, Young Jung, Sung, Bokyung, Jang, Jung Yoon, Ahn, Yu Ra, Oh, Hye Jin, Choi, Heejeong, Choi, Inkyu, Im, Eunok, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585637/
https://www.ncbi.nlm.nih.gov/pubmed/33073770
http://dx.doi.org/10.4062/biomolther.2020.153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585637/
https://www.ncbi.nlm.nih.gov/pubmed/33073770
http://dx.doi.org/10.4062/biomolther.2020.153

Ejemplares similares