Activation of ATM/Akt/CREB/eNOS Signaling Axis by Aphidicolin Increases NO Production and Vessel Relaxation in Endothelial Cells and Rat Aortas

Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been fully understood. Using a genotoxic agent aphidicolin, we investigated how DDRs regulate NO production...

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Detalles Bibliográficos
Autores principales: Park, Jung-Hyun, Cho, Du-Hyong, Hwang, Yun-Jin, Lee, Jee Young, Lee, Hyeon-Ju, Jo, Inho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585642/
https://www.ncbi.nlm.nih.gov/pubmed/32394671
http://dx.doi.org/10.4062/biomolther.2020.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585642/
https://www.ncbi.nlm.nih.gov/pubmed/32394671
http://dx.doi.org/10.4062/biomolther.2020.007

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